Nuclear envelope laminopathies: evidence for developmentally inappropriate chromatin-nuclear envelope interactions
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چکیده
منابع مشابه
Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies.
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins. A common feature of these diseases, named laminopathies, is the occurrence of major chromatin defects. We previously reported that cells from laminopathic patients show an altered nuclear profile, and ...
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In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm and the nucleoplasm, the nuclear envelope is now known to have roles in the cell cycle, cytoskeletal stability and cell migration, genome architect...
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The fifth U.K. meeting on nuclear envelope disease and chromatin brought together international experts from across the field of nuclear envelope biology to discuss the advancements in a class of tissue-specific degenerative diseases called the laminopathies. Clinically, these range from relatively mild fat-wasting disorders to the severe premature aging condition known as Hutchinson-Gilford pr...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2013
ISSN: 1756-8935
DOI: 10.1186/1756-8935-6-s1-p65